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Cordel et al.PMID:23539298 Malaria Journal 2013, 12:399 http://www.malariajournal.com/content/12/1/RESEARCHOpen AccessAtovaquoneproguanil in the therapy of imported uncomplicated Plasmodium falciparum malaria: a prospective observational study of 553 casesHugues Cordel1,two, Johann Cailhol1,two, Sophie Matheron3, Martine Bloch4, Nadine Godineau5, PaulHenri Consigny6, H e Gros7, Pauline Campa8, Patrice Bour 9, Olivier Fain10, Pascal Ralaimazava1 and Olivier Bouchaud1,2AbstractBackground: Every year, a huge number of instances of uncomplicated malaria are imported into Europe by travellers. Atovaquoneproguanil (AP) has been certainly one of the firstline regimens utilised in France for uncomplicated malaria for almost ten years. While AP’s efficacy and tolerance had been evaluated in many trials, its use in “real life” circumstances has never been described. This study aimed to describe outcome and tolerance right after AP remedy within a significant cohort of travellers returning from endemic locations. Techniques: Amongst September 2002 and January 2007, uncomplicated malaria treated in nine French travel clinics with AP have been followed for 30 days after AP initiation. Clinical and biological data were collected at admission and during the followup. Final results: A total of 553 sufferers have been.
